HRID1818372

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(Nc1nc(CBr)cs1)N(C1CCCCC1)C1CCCCC1

HCID86611183

未命名化合物

HCID178469909

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1c[nH]c(SCc2csc(NC(=O)N(C3CCCCC3)C3CCCCC3)n2)n1

HCID178469906

未命名化合物

收率 20%

结构：O=C(O)c1c[nH]c(SCc2csc(NC(=O)N(C3CCCCC3)C3CCCCC3)n2)n1

HCID178524801

未命名化合物

PROCEDURE

实验过程

2-[2-(3,3-Dicyclohexylureido)-thiazol-4-ylmethylsulfanyl)-1H-imidazole-4-carboxylic acid ethyl ester was prepared in 20% yield as described in general procedure L from 1,1-dicyclohexyl-3-(4-bromomethyl-thiazol-2-yl)urea and 2-mercapto-1H-imidazole-4-carboxylic acid ethyl ester. The ester (30 mg, 0.06 mmol) was hydrolysed using general procedure F to give 2-[2-(3,3-dicyclohexylureido)-thiazol-4-ylmethylsulfanyl)-1H-imidazole-4-carboxylic acid in 80% yield (22 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cb46f039e3bb402b8b1e917a89c179cd
来源数据集: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07598391B2
来源说明: uspto-grants-2009_10

反应 SMILES

[CH:1]1([N:7]([CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[C:8]([NH:10][C:11]2[S:12][CH:13]=[C:14]([CH2:16]Br)[N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:24]([O:26][C:27]([C:29]1[N:30]=[C:31]([SH:34])[NH:32][CH:33]=1)=[O:28])[CH3:25]>>[CH2:24]([O:26][C:27]([C:29]1[N:30]=[C:31]([S:34][CH2:16][C:14]2[N:15]=[C:11]([NH:10][C:8]([N:7]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[CH:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)=[O:9])[S:12][CH:13]=2)[NH:32][CH:33]=1)=[O:28])[CH3:25].[CH:1]1([N:7]([CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[C:8](=[O:9])[NH:10][C:11]2[S:12][CH:13]=[C:14]([CH2:16][S:34][C:31]3[NH:32][CH:33]=[C:29]([C:27]([OH:28])=[O:26])[N:30]=3)[N:15]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1