HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dicyclohexyl-3-(4-bromomethyl-thiazol-2-yl)urea → 2-[2-(3,3-Dicyclohexylureido)-thiazol-4-ylmethyl-sulfanyl)-1H-imidazole-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dicyclohexyl-3-(4-bromomethyl-thiazol-2-yl)urea | HCID 86611183 | — |
| Reactant | HCID 178469909 | HCID 178469909 | — |
| Product | 2-[2-(3,3-Dicyclohexylureido)-thiazol-4-ylmethyl-sulfanyl)-1H-imidazole-4-carboxylic acid ethyl ester | HCID 178469906 | 20% |
| Product | HCID 178524801 | HCID 178524801 | — |
Reaction Steps
2-[2-(3,3-Dicyclohexylureido)-thiazol-4-ylmethylsulfanyl)-1H-imidazole-4-carboxylic acid ethyl ester was prepared in 20% yield as described in general procedure L from 1,1-dicyclohexyl-3-(4-bromomethyl-thiazol-2-yl)urea and 2-mercapto-1H-imidazole-4-carboxylic acid ethyl ester. The ester (30 mg, 0.06 mmol) was hydrolysed using general procedure F to give 2-[2-(3,3-dicyclohexylureido)-thiazol-4-ylmethylsulfanyl)-1H-imidazole-4-carboxylic acid in 80% yield (22 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07598391B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-cb46f039e3bb402b8b1e917a89c179cd |
| Source note | uspto-grants-2009_10 |