2-Aminothiazole → HCID 11415501, compound

HRID 1818433Notes

Reaction equation

HRID 1818433 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]1.[C:8]1(=O)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[C:15](C1NC=CN=1)(C1NC=CN=1)=[O:16].[NH2:27][C:28]1[S:29][CH:30]=[CH:31][N:32]=1>>[CH:1]1([NH:7][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]1.[CH:1]1([N:7]([CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[C:15]([NH:27][C:28]2[S:29][CH:30]=[CH:31][N:32]=2)=[O:16])[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]1

Participants

6

Reactant 4

HCID 21552-AminothiazoleHCID 7967CyclohexanoneHCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 13040867HCID 13040867, compound

Product 2

HCID 11415501HCID 11415501, compoundHCID 65702898Cyclohex-3-enyl-cyclohexylamine

Procedure

Cyclohex-3-enyl-cyclohexylamine was prepared by reductive amination of cyclohex-3-enylamine and cyclohexanone using general procedure (B). Reaction with carbonyl diimidazole and 2-aminothiazole using general procedure (A) gave the title compound.

Sources & evidence

ORD record
ord-850a8e255fc74983b674e114ede1166a
Source dataset
uspto-grants-2009_10
Patent number
US07598391B2

Reaction notes

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