Hydroxyamine hydrochloride → HCID 178492604, compound

HRID 1818571Notes

Reaction equation

HRID 1818571 reaction equation
C([O-])(=O)C.[Na+].[CH3:6][O:7][C:8]1[CH:17]=[CH:16][C:11]([O:12][CH2:13][C:14]#[N:15])=[CH:10][CH:9]=1.Cl.[NH2:19][OH:20]>CO>[OH:20][NH:19][C:14](=[NH:15])[CH2:13][O:12][C:11]1[CH:16]=[CH:17][C:8]([O:7][CH3:6])=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 5794914-Methoxyphenoxyacetonitrile

Product 1

HCID 178492604HCID 178492604, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Add sodium acetate (5.1 g, 62 mmol) to 4-methoxyphenoxyacetonitrile (5.0 g, 31 mmol) and hydroxylamine hydrochloride (4.3 g, 62 mmol) in methanol (100 mL). Stir the resulting mixture at room temperature for 20 hours. Filter the resulting mixture through Celite, concentrate, stir in chloroform for 18 hours and filter. Concentrate the resulting solution to the title compound (5.1 g). LC-MS (m/e): 197 (M+1).

Workup

  1. filtrationFilter the resulting mixture through Celite
  2. concentrationconcentrate
  3. stirringstir in chloroform for 18 hours
  4. filtrationfilter
  5. concentrationConcentrate the resulting solution to the title compound (5.1 g)

Sources & evidence

ORD record
ord-dc6fb8a37e104b82bf9747f62857b046
Source dataset
uspto-grants-2009_10
Patent number
US07598423B2

Reaction notes

Loading…