1,1',1''-(Chlorosilylidyne)tris(benzene) → HCID 11634535, compound

HRID 1818666Notes

Reaction equation

HRID 1818666 reaction equation
[F:1][C@@H:2]1[C@@H:6]([CH2:7][OH:8])[O:5][C@@H:4]([N:9]2[CH:16]=[CH:15][C:13](=[O:14])[NH:12][C:10]2=[O:11])[CH2:3]1.[C:17]1([Si:23](Cl)([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>N1C=CC=CC=1>[F:1][C@@H:2]1[C@@H:6]([CH2:7][O:8][Si:23]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[O:5][C@@H:4]([N:9]2[CH:16]=[CH:15][C:13](=[O:14])[NH:12][C:10]2=[O:11])[CH2:3]1

Participants

4

Reactant 2

HCID 64581,1',1''-(Chlorosilylidyne)tris(benzene)HCID 1624502',3'-Dideoxy-3'-fluorouridine

Product 1

HCID 11634535HCID 11634535, compoundYield 60.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was synthesised following a similar procedure as described for Example 11. 3′-Fluoro-2′,3′-dideoxyuridine (0.214 g, 0.93 mmol) was reacted with triphenylsilyl chloride (0.332 g, 1.12 mmol) in dry pyridine (7 mL) for 3 h. to yield the title compound as a white solid (0.274 g, 60%).

Workup

  1. customThe title compound was synthesised

Sources & evidence

ORD record
ord-a864f108aaad429ca94cdd3aceef9eda
Source dataset
uspto-grants-2009_10
Patent number
US07601702B2

Reaction notes

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