Ammonium formate → HCID 57886251, compound

HRID 1818780Notes

Reaction equation

HRID 1818780 reaction equation
Cl.Cl.[CH:3]12[CH2:9][CH:6]([NH:7][CH2:8]1)[CH2:5][N:4]2[CH2:10][CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[N:14]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[S:13]1(=[O:28])=[O:27].C([O-])=O.[NH4+]>C(#N)C.CO>[CH:3]12[CH2:9][CH:6]([NH:7][CH2:8]1)[CH2:5][N:4]2[CH2:10][CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[N:14]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[S:13]1(=[O:27])=[O:28]

Participants

4

Reactant 2

HCID 2723923Ammonium formateHCID 68714842HCID 68714842, compound

Product 1

HCID 57886251HCID 57886251, compound

Reagents, catalysts & solvents 1

HCID 21959252Acetonitrile methanolSolvent

Procedure

Step 2 In an analogous manner as described in general procedure II, step 2, 1-[2-(2,5-diazabicyclo[2.2.1]hept-2-yl)ethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide dihydrochloride was prepared from tert-butyl-1-[2-(2,5-diazabicyclo[2.2.1]hept-2-yl)ethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide-4-carboxylate. MS (ES) m/z 371.2; HPLC purity 100.0% at 210-370 nm, 7.0 minutes; Xterra RP18, 3.5 u, 150×4.6 mm column, 1.2 mL/minutes 85/15-5/95 (Ammonium formate buffer pH=3.5/ACN+MeOH) for 10 minutes hold 4 minutes.

Workup

  1. customat 210-370 nm, 7.0 minutes

Sources & evidence

ORD record
ord-4d55e50408c947b09f33ecbc2097e8d8
Source dataset
uspto-grants-2009_10
Patent number
US07601722B2

Reaction notes

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