(R)-(-)-3-Bromo-2-methyl-1-propanol → HCID 46832501, compound

HRID 1818791Notes

Reaction equation

HRID 1818791 reaction equation
Br[CH2:2][C@H:3]([CH3:23])[CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])[S:6]1(=[O:22])=[O:21].FC1C=CC=C[C:26]=1[N:31]1C2C=CC=CC=2NS1(=O)=O.BrC[C@H](C)CO>>[F:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[N:7]1[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:5]([CH2:4][C@@H:3]([CH3:23])[CH2:2][NH:31][CH3:26])[S:6]1(=[O:22])=[O:21]

Participants

4

Reactant 3

HCID 10441885(R)-(-)-3-Bromo-2-methyl-1-propanolHCID 468330941-(2-Fluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxideHCID 68711261HCID 68711261, compound

Product 1

HCID 46832501HCID 46832501, compound

Procedure

In an analogous manner to Example 19, step 1, 1-[(2R)-3-bromo-2-methylpropyl]-3-(2-fluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide was prepared from 1-(2-fluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide and (R)-3-bromo-2-methylpropan-1-ol giving 0.27 g of the desired product.

Sources & evidence

ORD record
ord-4c32e01ea7234a05b1f431db8e11d5dd
Source dataset
uspto-grants-2009_10
Patent number
US07601722B2

Reaction notes

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