Methylamine → HCID 55299334, compound

HRID 1818807Notes

Reaction equation

HRID 1818807 reaction equation
[CH3:1][NH2:2].[F:3][C:4]([F:11])([CH2:9][OH:10])[C:5](OC)=[O:6]>CO>[F:3][C:4]([F:11])([CH2:9][OH:10])[C:5]([NH:2][CH3:1])=[O:6]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 17804449HCID 17804449, compound

Product 1

HCID 55299334HCID 55299334, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methylamine in methanol (33% wt, 10 mL) was added methyl 2,2-difluoro-3-hydroxypropanoate (1.0 g, 7.1 mmol) and the mixture stirred at room temperature overnight. After evaporation the residue was recrystallized from diethyl ether/hexanes to afford 2,2-difluoro-3-hydroxy-N-methylpropanamide.

Workup

  1. customAfter evaporation the residue
  2. customwas recrystallized from diethyl ether/hexanes

Sources & evidence

ORD record
ord-1af9496ddb304c32a6a5c32779a3826d
Source dataset
uspto-grants-2009_10
Patent number
US07601722B2

Reaction notes

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