HCID 68422863, compound → HCID 68425439, compound

HRID 1818919Notes

Reaction equation

HRID 1818919 reaction equation
[N+:1]([C:4]1[CH:22]=[CH:21][C:7]([CH2:8][NH:9][C:10]([C:12]2[C:13]3[S:20][CH:19]=[CH:18][C:14]=3[N:15]=[CH:16][N:17]=2)=[O:11])=[CH:6][CH:5]=1)([O-])=O>CO.O.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][NH:9][C:10]([C:12]2[C:13]3[S:20][CH:19]=[CH:18][C:14]=3[N:15]=[CH:16][N:17]=2)=[O:11])=[CH:21][CH:22]=1

Participants

4

Reactant 1

HCID 68422863HCID 68422863, compound

Product 1

HCID 68425439HCID 68425439, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 22242641Methanol--water (1/1)Solvent

Procedure

Compound 7.3 (1.0 mmol) and Pd/C (10 w/w %, 60 mg) in MeOH—H2O (12 mL) is stirred under a hydrogen atmosphere at room temperature until the reaction is complete. The catalyst is removed by filtration and the filtrate is evaporated to dryness under reduced pressure to provide thieno[3,2-d]pyrimidine-4-carboxylic acid 4-amino-benzylamide (compound 7.4).

Workup

  1. customThe catalyst is removed by filtration
  2. customthe filtrate is evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-4dd7e502aae74e529d34d5d8e4d3798e
Source dataset
uspto-grants-2009_10
Patent number
US07601725B2

Reaction notes

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