Hydrochloric Acid → HCID 68425697, compound

HRID 1818937Notes

Reaction equation

HRID 1818937 reaction equation
Cl.C(OC(=O)[NH:8][CH2:9][CH2:10][N:11]1[CH:15]=[C:14]([NH:16][C:17]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=2)=[O:18])[N:13]=[C:12]1[CH3:30])(C)(C)C>ClCCl>[NH2:8][CH2:9][CH2:10][N:11]1[CH:15]=[C:14]([NH:16][C:17]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=2)=[O:18])[N:13]=[C:12]1[CH3:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68425438HCID 68425438, compound

Product 1

HCID 68425697HCID 68425697, compoundYield 117.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4 N HCl in dioxanes (3 mL) was added to a solution of compound 40.3 (0.11 g, 0.26 mmol) in dichloromethane (3 mL). The reaction mixture stirred for 2 hours and concentrated to provide 1-[1-(2-amino-ethyl)-2-methyl-1H-imidazol-4-yl]-3-(3-trifluoromethyl-phenyl)-urea (compound 40.4; 0.10 g, 100%) as a HCl salt. ES (+) MS m/e=328(M+1).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-14f2683eb5654a1f887b03408f2d1c2d
Source dataset
uspto-grants-2009_10
Patent number
US07601725B2

Reaction notes

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