Phenyl isocyanate → HCID 57566922, compound

HRID 1819332Notes

Reaction equation

HRID 1819332 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH:22]4[CH2:26][CH2:25][CH2:24][CH2:23]4)[CH:14]=3)[CH2:10][C:9]2=[O:27])[CH:5]=[CH:6][CH:7]=1.[C:28]1([N:34]=[C:35]=[O:36])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>C(Cl)Cl>[CH:22]1([O:21][C:15]2[CH:14]=[C:13]([CH:11]3[CH2:12][N:8]([C:4]4[CH:3]=[C:2]([NH:1][C:35]([NH:34][C:28]5[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=5)=[O:36])[CH:7]=[CH:6][CH:5]=4)[C:9](=[O:27])[CH2:10]3)[CH:18]=[CH:17][C:16]=2[O:19][CH3:20])[CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 68828675HCID 68828675, compound

Product 1

HCID 57566922HCID 57566922, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1-(3-aminophenyl)-4-(3-cyclopentyloxy-4-methoxyphenyl)-pyrrolidin-2-one (8 mg, 0.022 mmol) in CH2Cl2 (0.5 mL) was created. Phenylisocyanate (0.023 mmol) was added, and the reaction mixture was stirred for 20 h. Concentration under reduced pressure and purification by column chromatography on silica gel (EtOAc:Hexane=1:2) gave the desired product.

Workup

  1. concentrationConcentration
  2. customunder reduced pressure and purification by column chromatography on silica gel (EtOAc:Hexane=1:2)

Sources & evidence

ORD record
ord-357ae435768449c280e5f66dc96eaf63
Source dataset
uspto-grants-2009_10
Patent number
US07601742B2

Reaction notes

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