HCID 57566815, compound → 1-(3-Aminophenyl)-4-(3-benzyloxy-4-methoxyphenyl)-pyrrolidin-2-one

HRID 1819345Notes

Reaction equation

HRID 1819345 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:17]2[CH2:21][N:20]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([N+:28]([O-])=O)[CH:23]=3)[C:19](=[O:31])[CH2:18]2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOC(C)=O.CCO.[Ni]>[NH2:28][C:24]1[CH:23]=[C:22]([N:20]2[CH2:21][CH:17]([C:11]3[CH:12]=[CH:13][C:14]([O:15][CH3:16])=[C:9]([O:8][CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH:10]=3)[CH2:18][C:19]2=[O:31])[CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 1

HCID 57566815HCID 57566815, compound

Product 1

HCID 99775741-(3-Aminophenyl)-4-(3-benzyloxy-4-methoxyphenyl)-pyrrolidin-2-one

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 21584252Ethanol ethylacetateSolvent

Procedure

To a solution of 4-(3-benzyloxy-4-methoxyphenyl)-1-(3-nitrophenyl)-pyrrolidin-2-one (100 mg) in EtOAc/EtOH (2 mL, 1:1) was added Raney Ni. The mixture was then put under vacuum and recharged with H2. The mixture was stirred under H2 for 10 h. After filtration, concentration gave crude product.

Workup

  1. filtrationAfter filtration, concentration
  2. customgave crude product

Sources & evidence

ORD record
ord-a54e3dc4c3a44f6094ba24923ff67fb8
Source dataset
uspto-grants-2009_10
Patent number
US07601742B2

Reaction notes

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