反应详情

A mixture of 3-(3-benzyloxyphenyl)-4-nitrobutyric acid ethyl ester (3.2 g) in 10 mL EtOAc and 20 mL EtOH was created in a dry round bottom flask. Raney Ni was added and the resulting mixture was stirred under H2 for 10 h at r.t. and filtered through celite. The solution was heated under reflux for 40 h, cooled to r.t., and concentrated. Chromatography of the residue on silica gel (EtOAc:Hexane=1:1 to 3:1) gave 1.89 g of the desired product.

1. customwas created in a dry round bottom flask
2. filtrationfiltered through celite
3. temperatureThe solution was heated
4. temperatureunder reflux for 40 h
5. temperaturecooled to r.t.
6. concentrationconcentrated