HuagongsheHuagongshe Chemistry Print Report · For research reference only
Rolipram → 3-[4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidin-1-yl]benzoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Rolipram | HCID 5092 | — |
| Reactant | Ethyl 3-bromobenzoate | HCID 90488 | — |
| Product | 3-[4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidin-1-yl]benzoic acid ethyl ester | HCID 68828453 | 67% |
Reaction Steps
A mixture of 4-(3-cyclopentyloxy-4-methoxyphenyl)-pyrrolidin-2-one (300 mg, 1.1 mmol) and 3-bromobenzoic acid ethyl ester (303 mg, 1.32 mmol) was treated according to General Procedure I to provide 310 mg of the desired product as a white solid. Yield: 67%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601742B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-78fae78460254ee68d4d1c4f482f0e82 |
| Source note | uspto-grants-2009_10 |