反应详情

(5-Nitro-2-trifluoromethoxy-phenyl)-methanol (2 g, 8.4 mmol) was dissolved in EtOAc (50 mL) and was degassed. Pd/C (200 mg) was then added and the mixture was degassed again. The solution was hydrogenated with a balloon for 3 h. After the reaction was complete, the solution was filtered through diatomaceous earth and the residue was chromatographed with 95:5 CH2Cl2:MeOH as an eluent to give 1.67 g (96%) of (5-amino-2-trifluoromethoxy-phenyl)-methanol as a yellow solid.

1. customwas degassed
2. additionPd/C (200 mg) was then added
3. customthe mixture was degassed again
4. filtrationthe solution was filtered through diatomaceous earth
5. customthe residue was chromatographed with 95:5 CH2Cl2