反应详情

温度

60 °C

3-[2-Acetyl-5-fluoro-3-(3-fluoro-benzyl)-benzofuran-7-yl]-pyrrole-1-carboxylic acid tert-butyl ester (0.114 gm, 0.253 mmol) and platinum (5% on carbon, 0.035 gm) were added to ethyl alcohol (45 ml) and placed under hydrogen (balloon) at 55° C. for two hours. Additional platinum (5% on carbon, 0.065 gm) was added and heated at 60° C. under hydrogen for three hours. The mixture was filtered, concentrated and purified by column chromatography (ethyl acetate/hexane gradient) to give 3-[2-acetyl-5-fluoro-3-(3-fluoro-benzyl)-benzofuran-7-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester (0.096 gm, 83% yield).

1. filtrationThe mixture was filtered
2. concentrationconcentrated
3. custompurified by column chromatography (ethyl acetate/hexane gradient)