Methylamine → HCID 16657078, compound

Participants

Reaction Steps

In an analogous manner to Example 2, step 6, 1-isopropyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (3R)-3-(3-isopropyl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl)-N-methyl-3-phenylpropan-1-amine hydrochloride was prepared from 1-[(1R)-3-chloro-1-phenylpropyl]-3-isopropyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide and methyl amine. MS (ES) m/z 360.1; HRMS: calculated for C19H25N3O2S+H+, 360.17402; found (ESI, [M+H]+), 360.1754; [□]D25=57.4° (c=10 mg/mL, MeOH).

Provenance & Evidence