Methylamine → HCID 16657078, compound

HRID 1819672Notes

Reaction equation

HRID 1819672 reaction equation
Cl.[CH:2]([N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]([C@@H:14]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:15][CH2:16][NH:17][CH3:18])[S:6]1(=[O:26])=[O:25])([CH3:4])[CH3:3].C(N1C2C=CC=CC=2NS1(=O)=O)(C)C.ClCC[C@@H](N1C2C=CC=CC=2N(C(C)C)S1(=O)=O)C1C=CC=CC=1.CN>CO>[CH:2]([N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]([C@@H:14]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:15][CH2:16][NH:17][CH3:18])[S:6]1(=[O:25])=[O:26])([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 6329MethylamineHCID 69062452HCID 69062452, compoundHCID 86611649HCID 86611649, compound

Product 1

HCID 16657078HCID 16657078, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In an analogous manner to Example 2, step 6, 1-isopropyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (3R)-3-(3-isopropyl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl)-N-methyl-3-phenylpropan-1-amine hydrochloride was prepared from 1-[(1R)-3-chloro-1-phenylpropyl]-3-isopropyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide and methyl amine. MS (ES) m/z 360.1; HRMS: calculated for C19H25N3O2S+H+, 360.17402; found (ESI, [M+H]+), 360.1754; [□]D25=57.4° (c=10 mg/mL, MeOH).

Sources & evidence

ORD record
ord-f4444dcff89a4fd08b688073422d04da
Source dataset
uspto-grants-2009_10
Patent number
US07601744B2

Reaction notes

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