Hydrochloric Acid → 1-[5-Fluoro-3-(3-fluoro-benzyl)-7-pyrrolidin-3-yl-benzofuran-2-yl]-ethanone

HRID 18197Notes

Reaction equation

HRID 18197 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([C:13]2[C:21]3[O:20][C:19]([C:22](=[O:24])[CH3:23])=[C:18]([CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[CH:27]=4)[C:17]=3[CH:16]=[C:15]([F:33])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[F:33][C:15]1[CH:14]=[C:13]([CH:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)[C:21]2[O:20][C:19]([C:22](=[O:24])[CH3:23])=[C:18]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[CH:27]=3)[C:17]=2[CH:16]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59344900HCID 59344900, compound

Product 1

HCID 249537791-[5-Fluoro-3-(3-fluoro-benzyl)-7-pyrrolidin-3-yl-benzofuran-2-yl]-ethanone

Procedure

1-[5-Fluoro-3-(3-fluoro-benzyl)-7-pyrrolidin-3-yl-benzofuran-2-yl]-ethanone was prepared by treating 3-[2-acetyl-5-fluoro-3-(3-fluoro-benzyl)-benzofuran-7-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester with ethanolic HCl using the procedure described for step 4 of Example 2, (M+H)+ 356.

Sources & evidence

ORD record
ord-e6b709addf1a428baae35ed80f093f7d
Source dataset
uspto-grants-2010_06
Patent number
US07741326B2

Reaction notes

Loading…