(7-fluoro-2-methyl-1H-indol-3-yl)acetic acid → n-(2,6-Dichloro-4-{n'-[2-(7-fluoro-2-methyl-1h-indol-3-yl)-acetyl]-guanidinomethyl}-phenyl)-acetamide

HRID 1819707Notes

Reaction equation

HRID 1819707 reaction equation
BrC1C=C2C(C(CC([N:14]=[C:15]([NH2:30])[NH:16][CH2:17][C:18]3[CH:23]=[C:22]([Cl:24])[C:21]([NH:25][C:26](=[O:28])[CH3:27])=[C:20]([Cl:29])[CH:19]=3)=O)=CN2)=CC=1.[F:31][C:32]1[CH:33]=[CH:34][CH:35]=[C:36]2[C:40]=1[NH:39][C:38]([CH3:41])=[C:37]2[CH2:42][C:43]([OH:45])=O>>[Cl:24][C:22]1[CH:23]=[C:18]([CH2:17][NH:16][C:15]([NH2:30])=[N:14][C:43](=[O:45])[CH2:42][C:37]2[C:36]3[C:40](=[C:32]([F:31])[CH:33]=[CH:34][CH:35]=3)[NH:39][C:38]=2[CH3:41])[CH:19]=[C:20]([Cl:29])[C:21]=1[NH:25][C:26](=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 4714944(7-fluoro-2-methyl-1H-indol-3-yl)acetic acidHCID 178474305HCID 178474305, compound

Product 1

HCID 178474303n-(2,6-Dichloro-4-{n'-[2-(7-fluoro-2-methyl-1h-indol-3-yl)-acetyl]-guanidinomethyl}-phenyl)-acetamide

Procedure

In a manner similar to that used in the preparation of the compound of example 1, but using 2-(7-fluoro-2-methyl-1H-indol-3-yl)acetic acid in step 22 (A), the title compound was prepared. MS (ESI) (M+H)+=464.00 1H-NMR(500 MHz, CD3OD) δ 7.44 (s, 2 H), 7.24 (d, J=7.93 Hz, 1 H), 6.90-7.01 (m, 1 H), 6.72-6.89 (m, 1 H), 4.52 (s, 2 H), 3.93 (s, 2 H), 2.45 (s, 3 H), 2.19 (s, 3 H).

Sources & evidence

ORD record
ord-b75cb0ffbab1416880c65b65e369c3a3
Source dataset
uspto-grants-2009_10
Patent number
US07601751B2

Reaction notes

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