HCID 18511494, compound → HCID 18511541, compound

HRID 1819801Notes

Reaction equation

HRID 1819801 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12](O)=O)[CH:5]=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1.[ClH:15].NC1[S:18][C:19]2[CH:25]=[CH:24][CH:23]=[C:22](Cl)[C:20]=2[N:21]=1>>[Cl:15][C:23]1[CH:24]=[CH:25][C:19]2[S:18][C:12]([CH2:11][C:4]3[CH:5]=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=[C:2]([Cl:1])[CH:3]=3)=[N:21][C:20]=2[CH:22]=1

Participants

3

Reactant 2

HCID 18511494HCID 18511494, compoundHCID 185116034-Chloro-1,3-benzothiazol-2-amine--hydrogen chloride (1/1)

Product 1

HCID 18511541HCID 18511541, compound

Procedure

5-Chloro-2-(3-chloro-5-nitro-benzyl)-benzothiazole (329) was synthesized (92%) from (3-chloro-5-nitro-phenyl)-acetic acid (328, 430 mg, 2.0 mmol) and 2-amino-4-chloro-benzothiazole hydrochloride (6, 392 mg, 2.0 mmol) in a similar manner as described in Example 8. 1H NMR (400 MHz, DMSO-d6) δ 8.30 (br s, 1H), 8.22 (t, J=2.0 Hz, 1H), 8.10 (d, J=8.6 Hz, 1H), 8.06 (d, J=2.0 Hz, 1H), 8.03 (br s, 1H), 7.47 (dd, J=8.6, 2.0 Hz, 1H), 4.72 (s, 2H). MS (EI): m/z 339 (M+H).

Sources & evidence

ORD record
ord-4a4a89bad8ce46e88603ca783a3de321
Source dataset
uspto-grants-2009_10
Patent number
US07601841B2

Reaction notes

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