4-Aminophenol → HCID 18511552, compound

HRID 1819809Notes

Reaction equation

HRID 1819809 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[Cl:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:11]=1[S:20](Cl)(=[O:22])=[O:21]>>[Cl:9][C:10]1[CH:15]=[C:14]([C:16]([F:18])([F:17])[F:19])[CH:13]=[CH:12][C:11]=1[S:20]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1)(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 4034-AminophenolHCID 27366752-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride

Product 1

HCID 18511552HCID 18511552, compound

Procedure

2-Chloro-N-(4-hydroxy-phenyl)-4-trifluoromethyl-benzenesulfonamide was synthesized (98%) from 4-aminophenol (Aldrich) and 2-chloro-4-trifluoromethylbenzenesulfonyl chloride in a similar manner as described in Example 421. 1H NMR (400 MHz, DMSO-d6) δ 10.30 (s, 1H), 9.39 (s, 1H), 8.12 (s, 1H), 8.06 (d, J=8.2 Hz, 1H), 7.85 (d, J=8.1 Hz, 1H), 6.89 (m, 2H), 6.61 (m, 2H). MS (EI): m/z 384 (M+H).

Sources & evidence

ORD record
ord-fecc15174dee40bbb99ccd16240111cc
Source dataset
uspto-grants-2009_10
Patent number
US07601841B2

Reaction notes

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