Cyclohexylacetyl chloride → HCID 24899956, compound

HRID 1819876Notes

Reaction equation

HRID 1819876 reaction equation
[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:15].[CH:16]1([CH2:22][C:23](Cl)=[O:24])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>N1C=CC=CC=1>[CH:16]1([CH2:22][C:23]([NH:15][C:2]2[CH:3]=[CH:4][C:5]3[O:6][C:7]4[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:8]=4[C:9]=3[CH:1]=2)=[O:24])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 2757989Cyclohexylacetyl chlorideHCID 128848837,8,9,10-tetrahydro-6H-benzo[b]-cyclohepta[d]furan-2-ylamine

Product 1

HCID 24899956HCID 24899956, compoundYield 36.2%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Following the procedure of Example 1, 7,8,9,10-tetrahydro-6H-benzo[b]-cyclohepta[d]furan-2-ylamine (0.91 g, 4.5 mmol) and cyclohexylacetyl chloride (0.80 g, 5.0 mmol) in pyridine (10 mL) provided 2-cyclohexyl-N-[7,8,9,10-tetrahydro-6H-benzo[b]-cyclohepta[d]furan-2-yl]acetamide (0.53 g). Mp 188-189° C.; Anal. Calcd. for C21H27NO2: C, 77.50; H, 8.36; N, 4.30; Found: C, 77.51; H, 8.43; N, 4.32.

Sources & evidence

ORD record
ord-cd9cc5a2fc6b47dc8659846d662106bc
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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