Dichloromethane → HCID 57890300, compound

HRID 1819893Notes

Reaction equation

HRID 1819893 reaction equation
[CH3:1][C@H:2]([NH:20]C(=O)OC(C)(C)C)[C:3](=[O:19])[NH:4][C:5]1[CH:18]=[CH:17][C:8]2[O:9][C:10]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][C:11]=3[C:7]=2[CH:6]=1.ClCCl.O1CCO[CH2:33][CH2:32]1>Cl>[CH:6]1[C:7]2[C:11]3[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:10]=3[O:9][C:8]=2[CH:17]=[CH:18][C:5]=1[NH:4][C:3](=[O:19])[C@@H:2]1[CH2:1][CH2:33][CH2:32][NH:20]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 24897210HCID 24897210, compound

Product 1

HCID 57890300HCID 57890300, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of tert-butyl [(1S)-1-methyl-2-oxo-2-(7,8,9,10-tetrahydro-6H-benzo[b]cyclohepta[d]furan-2-ylamino)ethyl]carbamate (0.10 g) in 4 N HCl in dioxane (3 mL) and dichloromethane (3 mL) was stirred at room temperature for 30 min and then concentrated to provide N-7,8,9,10-tetrahydro-6H-benzo[b]cyclohepta[d]furan-2-yl-L-prolinamide (46 mg) as its hydrochloric acid salt. MS (ESI) m/z 299 ([M+H]+).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-b2a1713ccef94b4a8bccf1e095be6348
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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