Cyclohexylacetyl chloride → HCID 24897430, compound

HRID 1819901Notes

Reaction equation

HRID 1819901 reaction equation
[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:16].[CH:17]1([CH2:23][C:24](Cl)=[O:25])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>N1C=CC=CC=1>[CH:17]1([CH2:23][C:24]([NH:16][C:2]2[CH:3]=[CH:4][C:5]3[O:6][C:7]4[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:8]=4[C:9]=3[CH:1]=2)=[O:25])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 2757989Cyclohexylacetyl chlorideHCID 57890287HCID 57890287, compound

Product 1

HCID 24897430HCID 24897430, compoundYield 76.6%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Following the procedure of Example 1, 6,7,8,9,10,11-Hexahydro-benzo[b]-cycloocta[d]furan-2-ylamine (1.1 g, 5.0 mmol) and cyclohexylacetyl chloride (0.88 g, 5.5 mmol) in pyridine (10 mL) provided 2-cyclohexyl-N-[6,7,8,9,10,11-hexahydro-benzo[b]-cycloocta[d]furan-2-yl]acetamide (1.3 g). Mp 180-181° C.;MS (El) m/z 340 ([M+H]+); Anal. Calcd. for C22H29NO2: C, 77.84; H, 8.61; N, 4.13; Found: C, 77.96; H, 8.70; N, 4.16.

Sources & evidence

ORD record
ord-7ce4b0e283984ccc8404aeb29cb500c4
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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