3-Cyclopentylpropionyl chloride → HCID 24897638, compound

HRID 1819906Notes

Reaction equation

HRID 1819906 reaction equation
[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:16].[CH:17]1([CH2:22][CH2:23][C:24](Cl)=[O:25])[CH2:21][CH2:20][CH2:19][CH2:18]1>ClCCl>[CH:17]1([CH2:22][CH2:23][C:24]([NH:16][C:2]2[CH:3]=[CH:4][C:5]3[O:6][C:7]4[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:8]=4[C:9]=3[CH:1]=2)=[O:25])[CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 660393-Cyclopentylpropionyl chlorideHCID 57890287HCID 57890287, compound

Product 1

HCID 24897638HCID 24897638, compoundYield 63.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the procedure of Example 1, 6,7,8,9,10,11-Hexahydro-benzo[b]-cycloocta[d]furan-2-ylamine (0.13 g, 0.60 mmol), 3-cyclopentylpropionyl chloride (0.10 g, 0.63 mmol), and poly(vinylpyridine) (0.5 g) in dichloromethane (15 mL) provided 3-cyclopentyl-N-(6,7,8,9,10,11-hexahydrobenzo[b]cycloocta[d]furan-2-yl)propanamide (0.13 g). MS (ESI) m/z 340 ([M+H]+).

Sources & evidence

ORD record
ord-f17506219e01424f82e130bca0d40237
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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