Hexanoyl chloride → HCID 24897634, compound

HRID 1819907Notes

Reaction equation

HRID 1819907 reaction equation
[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:16].[C:17](Cl)(=[O:23])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>ClC(Cl)C>[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH:16][C:17](=[O:23])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Participants

4

Reactant 2

HCID 67340Hexanoyl chlorideHCID 57890287HCID 57890287, compound

Product 1

HCID 24897634HCID 24897634, compoundYield 46.2%

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

Following the procedure of Example 1, 6,7,8,9,10,11-Hexahydro-benzo[b]-cycloocta[d]furan-2-ylamine (0.15 g, 0.69 mmol), hexanoyl chloride (0.098 mL, 0.69 mmol), and poly(vinylpyridine) (0.5 g) in dichloroethane (8 mL) provided N-(6,7,8,9,10,11-hexahydrobenzo[b]cycloocta[d]furan-2-yl)hexanamide (0.10 g). MS (ESI) m/z 314 ([M+H]+).

Sources & evidence

ORD record
ord-88813eaca80040cbbc1840fd7c0fefd7
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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