Acetyl chloride → HCID 24897636, compound

HRID 1819909Notes

Reaction equation

HRID 1819909 reaction equation
[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:16].[C:17](Cl)(=[O:19])[CH3:18]>ClC(Cl)C>[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH:16][C:17](=[O:19])[CH3:18]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 57890287HCID 57890287, compound

Product 1

HCID 24897636HCID 24897636, compoundYield 56.3%

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

Following the procedure of Example 1, 6,7,8,9,10,11-Hexahydro-benzo[b]-cycloocta[d]furan-2-ylamine (0.15 g, 0.69 mmol), acetyl chloride (0.055 mL, 0.69 mmol), and poly(vinylpyridine) (0.5 g) in dichloroethane (8 mL) provided N-(6,7,8,9,10,11-hexahydrobenzo[b]cycloocta[d]furan-2-yl)acetamide (0.10 g). MS (ESI) m/z 258 ([M+H]+).

Sources & evidence

ORD record
ord-494217b6d5a9472090ed510bc2fa45bc
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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