Phenylacetyl chloride → HCID 24897639, compound

HRID 1819911Notes

Reaction equation

HRID 1819911 reaction equation
[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:16].[C:17]1([CH2:23][C:24](Cl)=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>ClC(Cl)C>[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH:16][C:24](=[O:25])[CH2:23][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 7679Phenylacetyl chlorideHCID 57890287HCID 57890287, compound

Product 1

HCID 24897639HCID 24897639, compoundYield 81.5%

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

Following the procedure of Example 1, 6,7,8,9,10,11-Hexahydro-benzo[b]-cycloocta[d]furan-2-ylamine (0.20 g, 0.92 mmol), phenylacetyl chloride (0.14 mL, 1.0 mmol), and poly(vinylpyridine) (0.5 g) in dichloroethane (12 mL) provided N-(6,7,8,9,10,11-hexahydrobenzo[b]cycloocta[d]furan-2-yl)-2-phenylacetamide (0.25 g). MS (ESI) m/z 334.3 ([M+H]+).

Sources & evidence

ORD record
ord-dc7daa821bb9444195114a97293e310f
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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