2,6-Dimethoxybenzoyl chloride → HCID 24897851, compound

HRID 1819912Notes

Reaction equation

HRID 1819912 reaction equation
[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:16].[CH3:17][O:18][C:19]1[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[C:20]=1[C:21](Cl)=[O:22]>ClC(Cl)C>[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH:16][C:21](=[O:22])[C:20]1[C:24]([O:28][CH3:29])=[CH:25][CH:26]=[CH:27][C:19]=1[O:18][CH3:17]

Participants

4

Reactant 2

HCID 748102,6-Dimethoxybenzoyl chlorideHCID 57890287HCID 57890287, compound

Product 1

HCID 24897851HCID 24897851, compound

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

Following the procedure of Example 1, 6,7,8,9,10,11-Hexahydro-benzo[b]-cycloocta[d]furan-2-ylamine (0.15 g, 0.69 mmol), 2,6-dimethoxybenzoyl chloride (0.15 mL, 0.77 mmol), and poly(vinylpyridine) (0.5 g) in dichloroethane (12 mL) N-(6,7,8,9,10,11-hexahydrobenzo[b]cycloocta[d]furan-2-yl)-2,6-dimethoxybenzamide (0.15 g). MS (ESI) m/z 380 ([M+H]+).

Sources & evidence

ORD record
ord-7697cb8160a64bf990612c6df0630486
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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