Pyridine → HCID 24897854, compound

HRID 1819915Notes

Reaction equation

HRID 1819915 reaction equation
[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:16].[Cl:17][CH2:18][C:19](Cl)=[O:20].N1C=CC=CC=1>ClC(Cl)C>[Cl:17][CH2:18][C:19]([NH:16][C:2]1[CH:3]=[CH:4][C:5]2[O:6][C:7]3[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:8]=3[C:9]=2[CH:1]=1)=[O:20]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6577Chloroacetyl chlorideHCID 57890287HCID 57890287, compound

Product 1

HCID 24897854HCID 24897854, compoundYield 101.9%

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

Following the procedure of Example 1, 6,7,8,9,10,11-Hexahydro-benzo[b]-cycloocta[d]furan-2-ylamine (0.80 g, 3.7 mmol), chloroacetyl chloride (0.31 mL, 3.9 mmol), and pyridine (0.60 mL, 7.4 mmol) in dichloroethane (25 mL) provided 2-chloro-N-6,7,8,9,10,11-hexahydrobenzo[b]cycloocta[d]furan-2-ylacetamide (1.1 g). MS (ESI) m/z 292 ([M+H]+).

Sources & evidence

ORD record
ord-13c5267a6a4f49f28c25694bb40f3106
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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