Methanol → Methyl 4-hydroxy-3-methylbenzoate

HRID 1819925Notes

Reaction equation

HRID 1819925 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6].[CH3:12]O>>[CH3:12][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([OH:11])=[C:2]([CH3:1])[CH:3]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 681384-Hydroxy-3-methylbenzoic acid

Product 1

HCID 11240684Methyl 4-hydroxy-3-methylbenzoate

Procedure

To a mixture of 3-methyl-4-hydroxybenzoic acid (342 g, 2.24 mol) in MeOH (3.5 I) is bubbled HCl (g) for 5 m. The mixture is stirred for 12 h at RT. The reaction is concentrated to give the title compound (372 g, quant).

Workup

  1. customis bubbled HCl (g) for 5 m
  2. concentrationThe reaction is concentrated

Sources & evidence

ORD record
ord-d397260e9acb48b1b6f809ff7490b7b3
Source dataset
uspto-grants-2009_10
Patent number
US07601850B2

Reaction notes

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