HCID 57890029, compound → HCID 57890157, compound

HRID 1819959Notes

Reaction equation

HRID 1819959 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([C:10]([CH2:19][CH3:20])([C:13]2[S:14][CH:15]=[C:16]([CH3:18])[CH:17]=2)[CH2:11][CH3:12])=[CH:6][C:5]=1[CH3:21]>C1COCC1>[CH2:11]([C:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:3][OH:2])=[C:5]([CH3:21])[CH:6]=1)([C:13]1[S:14][CH:15]=[C:16]([CH3:18])[CH:17]=1)[CH2:19][CH3:20])[CH3:12]

Participants

3

Reactant 1

HCID 57890029HCID 57890029, compound

Product 1

HCID 57890157HCID 57890157, compoundYield 98.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a 0° C. solution of 4-[1-ethyl-1-(4-methyl-thiophen-2-yl)-propyl]-2-methyl-benzoic acid methyl ester (6.7 g, 21.2 mmol) in THF (100 ml) is added 1M LiA1H4/THF (32 ml, 32 mmol). After stirring at RT for 2 h, the reaction is quenched with water (1 ml) followed by 5N NaOH solution (1 ml) and water (3 ml). The mixture is filtered and the filtrate is concentrated to give the title compound as a clear oil (6 g, 98%).

Workup

  1. customthe reaction is quenched with water (1 ml)
  2. filtrationThe mixture is filtered
  3. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-1238610087794ca68beae201a4263bd7
Source dataset
uspto-grants-2009_10
Patent number
US07601850B2

Reaction notes

Loading…