Lithium Hydroxide → HCID 10477025, compound

HRID 1819963Notes

Reaction equation

[Li+].[OH-].C[O:4][C:5]([C:7]1[S:8][C:9]([C:13]([CH2:31][CH3:32])([C:16]2[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH:24]([OH:29])[C:25]([CH3:28])([CH3:27])[CH3:26])=[C:18]([CH3:30])[CH:17]=2)[CH2:14][CH3:15])=[CH:10][C:11]=1[CH3:12])=[O:6]>>[CH2:14]([C:13]([C:9]1[S:8][C:7]([C:5]([OH:6])=[O:4])=[C:11]([CH3:12])[CH:10]=1)([C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH:24]([OH:29])[C:25]([CH3:27])([CH3:28])[CH3:26])=[C:18]([CH3:30])[CH:17]=1)[CH2:31][CH3:32])[CH3:15]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 10365416HCID 10365416, compound

Product 1

HCID 10477025HCID 10477025, compoundYield 94%

Procedure

Using LiOH hydrolysis as described in Example 137, 5-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-methyl-thiophene-2-carboxylic acid methyl ester gives the title compound (94%).

Sources & evidence

ORD record: ord-f96acaa029f74ec48b5d274e52aa63a8
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07601850B2

Reaction notes

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