Lithium Hydroxide → HCID 10097831, compound

HRID 1819966Notes

Reaction equation

[Li+].[OH-].C[O:4][C:5](=[O:7])[CH3:6].[CH2:8]([C:10]([C:28]1[S:32][C:31]([S:33]([NH2:36])(=[O:35])=[O:34])=[C:30]([CH3:37])[CH:29]=1)([C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][CH:21]([OH:26])[C:22]([CH3:25])([CH3:24])[CH3:23])=[C:15]([CH3:27])[CH:14]=1)[CH2:11][CH3:12])[CH3:9]>>[CH2:8]([C:10]([C:28]1[S:32][C:31]([S:33]([NH:36][CH2:6][C:5]([OH:4])=[O:7])(=[O:35])=[O:34])=[C:30]([CH3:37])[CH:29]=1)([C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][CH:21]([OH:26])[C:22]([CH3:24])([CH3:25])[CH3:23])=[C:15]([CH3:27])[CH:14]=1)[CH2:11][CH3:12])[CH3:9]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68625813HCID 68625813, compound

Product 1

HCID 10097831HCID 10097831, compound

Procedure

Using LiOH hydrolysis as described in Example 136, (5-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-3-methyl-thiophene-2-sulfonylamine)-acetic acid methyl ester gives the title compound (quant).

Sources & evidence

ORD record: ord-2bee380f75634dbea613c2e71e946128
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07601850B2

Reaction notes

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