Lithium Hydroxide → HCID 68625416, compound

HRID 1819968Notes

Reaction equation

[Li+].[OH-].C[O:4][C:5](=[O:7])[CH3:6].[CH3:8][C:9]([CH3:37])([CH3:36])[C:10](=[O:35])[CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([C:24]2[S:28][C:27]([S:29]([NH2:32])(=[O:31])=[O:30])=[C:26]([CH3:33])[CH:25]=2)([CH2:22][CH3:23])[CH2:20][CH3:21])=[CH:15][C:14]=1[CH3:34]>>[C:5]([OH:7])(=[O:4])[CH3:6].[CH3:37][C:9]([CH3:8])([CH3:36])[C:10](=[O:35])[CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([C:24]2[S:28][C:27]([S:29]([NH2:32])(=[O:31])=[O:30])=[C:26]([CH3:33])[CH:25]=2)([CH2:22][CH3:23])[CH2:20][CH3:21])=[CH:15][C:14]=1[CH3:34]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68625259HCID 68625259, compound

Product 1

HCID 68625416HCID 68625416, compound

Procedure

Using LiOH hydrolysis as described in Example 137, (5-{1-[4-(4,4-dimethyl-3-oxo-pentyl)-3-methyl-phenyl]-1-ethyl-propyl}-3-methyl-thiophene-2-sulfonylamine)-acetic acid methyl ester gives the title compound (quant).

Sources & evidence

ORD record: ord-ad4f1e2022674b2385255cb744c29077
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07601850B2

Reaction notes

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