反应详情

温度

10 °C

2,4,6-Trifluoronitrobenzene (4.95 g) and potassium carbonate (4.63 g) were mixed in dry dimethyl sulfoxide (40 mL) and cooled to 10° C. under argon. Morpholine (2.56 mL) was added and the reaction mixture was allowed to warm to 25° C. and stirred under argon for 16 hours. The reaction mixture was concentrated in vacuo, brine (50 mL) was added and the product was extracted with ethyl acetate (3×50 mL), the combined organic phases were dried over magnesium sulfate and concentrated in vacuo. The crude material was purified by flash chromatography to furnish 3.69 g (54% yield) of the title compound as a yellow oil.

1. temperatureto warm to 25° C.
2. concentrationThe reaction mixture was concentrated in vacuo, brine (50 mL)
3. additionwas added
4. extractionthe product was extracted with ethyl acetate (3×50 mL)
5. dry with materialthe combined organic phases were dried over magnesium sulfate
6. concentrationconcentrated in vacuo
7. customThe crude material was purified by flash chromatography