Hydrochloric Acid → HCID 67299615, compound

HRID 1820161Notes

Reaction equation

HRID 1820161 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][N:12]([C:15](=[O:27])[C@H:16]([NH:19]C(=O)OC(C)(C)C)[CH2:17][CH3:18])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1>O1CCOCC1>[ClH:2].[NH2:19][C@H:16]([CH2:17][CH3:18])[C:15]([N:12]1[CH2:13][CH2:14][CH:9]([C:6]2[CH:5]=[CH:4][C:3]([Cl:2])=[CH:8][CH:7]=2)[CH2:10][CH2:11]1)=[O:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57888901HCID 57888901, compound

Product 1

HCID 67299615HCID 67299615, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 4M solution of HCl in dioxane (8 mL) was added to (R)-tert-butyl 1-(4-(4-chlorophenyl)piperidin-1-yl)-1-oxobutan-2-ylcarbamate (0.46 g) and the resulting solution was allowed to stir at rt. for 1.5 h. After this time, the solvent was removed by rotary evaporation to provide an oil. The oil was dried overnight in vacuo to provide (R)-2-amino-1-(4-(4-chlorophenyl)piperidin-1-yl)butan-1-one hydrochloride. MS found: (M+H)+=281.

Workup

  1. customAfter this time, the solvent was removed by rotary evaporation
  2. customto provide an oil
  3. customThe oil was dried overnight in vacuo

Sources & evidence

ORD record
ord-e9061fa950234750905c1ac75b67d900
Source dataset
uspto-grants-2009_10
Patent number
US07601844B2

Reaction notes

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