Dichloromethane → Trifluoroacetic acid

HRID 182019Notes

Reaction equation

HRID 182019 reaction equation
[Cl:32][CH2:33][Cl:34].[F:25][C:26]([C:27](=[O:28])[OH:29])([F:30])[F:31].[O:1]=[C:2]1[NH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH2:10][N:11]1[CH:12]1[CH2:13][CH2:14][N:15]([C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:16][CH2:17]1>>[F:25][C:26]([C:27](=[O:28])[OH:29])([F:30])[F:31].[O:1]=[C:2]1[NH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH2:10][N:11]1[CH:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 53415303tert-Butyl 4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 110425973-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one

Sources & evidence

ORD record
ord-99f022671fc646a38b11a0a417fe9412
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…