Hydrochloric Acid → HCID 19965411, compound

HRID 1820256Notes

Reaction equation

HRID 1820256 reaction equation
C[O:2][C:3](=[O:17])[C:4]([C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([O:12]C)=[O:11])([CH3:6])[CH3:5].[OH-].[Na+].Cl.[Cl-].[Na+]>CO>[C:3]([C:4]([C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([OH:12])=[O:11])([CH3:6])[CH3:5])([OH:17])=[O:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 13657964HCID 13657964, compound

Product 1

HCID 19965411HCID 19965411, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 3-(1-methoxy-2-methyl-1-oxopropan-2-yl)benzoate (54 mg, 0.229 mmol) in methanol (2 mL) was treated with 1 M NaOH (aq) (1 mL, 1.000 mmol), and the mixture was stirred overnight at room temperature. The mixture was treated with 1.0 N HCl (aq) (1.2 mL), and the methanol was removed in-vacuo. The remaining aqueous mixture was freeze dried to yield a mixture of the title compound and sodium chloride as colorless powder, which was used as-is in the next step.

Workup

  1. customthe methanol was removed in-vacuo
  2. customdried
  3. customto yield

Sources & evidence

ORD record
ord-73fa4d02e933462da293a6a5dce3721d
Source dataset
uspto-grants-2009_10
Patent number
US07601844B2

Reaction notes

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