Octahydropyrrolo(1,2-a)pyrazine → HCID 68682026, compound

HRID 1820372Notes

Reaction equation

HRID 1820372 reaction equation
[N:1]1([C:7]([C:9]2[N:10]([CH2:21][C:22]([F:25])([F:24])[F:23])[C:11]3[C:16]([CH:17]=2)=[CH:15][C:14]([C:18](O)=[O:19])=[CH:13][CH:12]=3)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[N:26]12[CH2:34][CH2:33][CH2:32][CH:31]1[CH2:30][NH:29][CH2:28][CH2:27]2>>[CH2:30]1[N:29]([C:18]([C:14]2[CH:15]=[C:16]3[C:11](=[CH:12][CH:13]=2)[N:10]([CH2:21][C:22]([F:25])([F:23])[F:24])[C:9]([C:7]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[O:8])=[CH:17]3)=[O:19])[CH2:28][CH2:27][N:26]2[CH2:34][CH2:33][CH2:32][CH:31]12

Participants

3

Reactant 2

HCID 558578Octahydropyrrolo(1,2-a)pyrazineHCID 686815812-(Morpholine-4-carbonyl)-1-(2,2,2-trifluoro-ethyl)-1H-indole-5-carboxylic acid

Product 1

HCID 68682026HCID 68682026, compoundYield 65%

Procedure

The title compound was synthesized in analogy to example 46, intermediate e), from 2-(morpholine-4-carbonyl)-1-(2,2,2-trifluoro-ethyl)-1H-indole-5-carboxylic acid and 1,4-diazabicyclo[4.3.0]nonane (purchased at Matrix Ref 8078), to give the desired product as a white solid (65%).

Sources & evidence

ORD record
ord-181144088882444fb494b7753f86ac52
Source dataset
uspto-grants-2009_10
Patent number
US07601711B2

Reaction notes

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