Pyridine → 1-Cyclopropyl-8-(4-ethyl-1-piperazinyl)-7-fluoro-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid

HRID 182046Notes

Reaction equation

HRID 182046 reaction equation
[CH2:24]([CH3:25])[N:26]1[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]1.[Cl:1][c:2]1[c:3]([F:23])[cH:4][c:5]2[c:6]([n:7][c:8]3[n:9]([CH:19]4[CH2:20][CH2:21]4)[cH:10][c:11]([C:16](=[O:17])[OH:18])[c:12](=[O:15])[c:13]3[cH:14]2)[cH:22]1.[cH:32]1[cH:33][cH:34][n:35][cH:36][cH:37]1>>[c:2]1([N:29]2[CH2:28][CH2:27][N:26]([CH2:24][CH3:25])[CH2:31][CH2:30]2)[c:3]([F:23])[cH:4][c:5]2[c:6]([n:7][c:8]3[n:9]([CH:19]4[CH2:20][CH2:21]4)[cH:10][c:11]([C:16](=[O:17])[OH:18])[c:12](=[O:15])[c:13]3[cH:14]2)[cH:22]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 791961-EthylpiperazineHCID 147005568-Chloro-1-cyclopropyl-7-fluoro-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid

Product 1

HCID 147005761-Cyclopropyl-8-(4-ethyl-1-piperazinyl)-7-fluoro-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid

Sources & evidence

ORD record
ord-e8aa0c473d744fc480659a3de67c8a5c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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