HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetonitrile → HCID 68680709, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetonitrile | HCID 11534 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | [2-(1,1-Dioxo-thiomorpholine-4-carbonyl)-1H-indol-5-yl]-(4-isopropyl-piperazin-1-yl)-methanone | HCID 68681206 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68680709 | HCID 68680709 | 11% |
Reaction Steps
The title compound was synthesized in analogy to example 51, from [2-(1,1-dioxo-thiomorpholine-4-carbonyl)-1H-indol-5-yl]-(4-isopropyl-piperazin-1-yl)-methanone (example 1), sodium hydride and bromoacetonitrile in N,N-dimethylformamide, to give the desired product as a brown gum (11%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601711B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-d6baef43eab74adaa282a4bd9753b0d1 |
| Source note | uspto-grants-2009_10 |