Morpholine → HCID 68682539, compound

HRID 1820553Notes

Reaction equation

HRID 1820553 reaction equation
[CH3:1][N:2]([CH3:23])[CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15]([C:20](O)=[O:21])=[CH:14]3)=[O:10])[CH2:4]1.[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1.Cl.C(N=C=NCCCN(C)C)C>>[CH3:1][N:2]([CH3:23])[CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15]([C:20]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)=[O:21])=[CH:14]3)=[O:10])[CH2:4]1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 68680406HCID 68680406, compound

Product 1

HCID 68682539HCID 68682539, compound

Procedure

The title compound was synthesized in analogy to Example 1, from 5-(3-dimethylamino-piperidine-1-carbonyl)-1H-indole-2-carboxylic acid, morpholine and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride, to afford the product as an off-white solid (37%).

Sources & evidence

ORD record
ord-404206027def44ce8d6b873673c0aeb2
Source dataset
uspto-grants-2009_10
Patent number
US07601711B2

Reaction notes

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