Phosphorus oxychloride → 4-Chloro-6-(trifluoromethyl)pyrimidine

HRID 1820714Notes

Reaction equation

HRID 1820714 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[N:8]=[CH:7][N:6]=[C:5](O)[CH:4]=1.P(Cl)(Cl)([Cl:14])=O>>[Cl:14][C:5]1[CH:4]=[C:3]([C:2]([F:11])([F:10])[F:1])[N:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178516143HCID 178516143, compound

Product 1

HCID 115428814-Chloro-6-(trifluoromethyl)pyrimidine

Procedure

6-Trifluoromethyl-pyrimidin-4-ol ([1546-78-7], 5 g) was refluxed in phosphorus oxychloride (17 mL) for 2 hours. The reaction mixture was carefully concentrated in vacuo and the residue was distilled (Kugelrohr) under reduced pressure (bp=30-55° C.@10 mbar) to yield the title compound ([37552-81-1], 1.4 g). MS (EI): 182.0 (M).

Workup

  1. concentrationThe reaction mixture was carefully concentrated in vacuo
  2. distillationthe residue was distilled (Kugelrohr) under reduced pressure (bp=30-55° C.@10 mbar)

Sources & evidence

ORD record
ord-1d001d3be51b4dc395fc6562aa9ad39d
Source dataset
uspto-grants-2009_10
Patent number
US07605163B2

Reaction notes

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