Hydrochloric Acid → HCID 68822041, compound

HRID 1820722Notes

Reaction equation

HRID 1820722 reaction equation
C[O:2][C:3](=[O:21])[C:4]1[CH:9]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:7]=[CH:6][C:5]=1[O:14][CH2:15][CH2:16][C:17]([F:20])([F:19])[F:18].[OH-].[Na+].Cl>C(O)C>[CH3:13][S:10]([C:8]1[CH:7]=[CH:6][C:5]([O:14][CH2:15][CH2:16][C:17]([F:18])([F:20])[F:19])=[C:4]([CH:9]=1)[C:3]([OH:21])=[O:2])(=[O:12])=[O:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69036106HCID 69036106, compound

Product 1

HCID 68822041HCID 68822041, compoundYield 83.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 5-methanesulfonyl-2-(3,3,3-trifluoro-propoxy)-benzoic acid methyl ester (620 mg) in ethanol at 60° C. was added 1N NaOH solution (3.8 mL), and the reaction mixture was stirred for 15 minutes. After such time, 3.8 ml of 1N HCl was slowly added to the reaction mixture, and the ethanol was evaporated in vacuo. The precipitate was then washed with water several times to give the title compound (497 mg). MS (m/e): 311.0, M−H+, 100%).

Workup

  1. customthe ethanol was evaporated in vacuo
  2. washThe precipitate was then washed with water several times

Sources & evidence

ORD record
ord-006c7b1cfa1649afa1679ea939bf2bf8
Source dataset
uspto-grants-2009_10
Patent number
US07605163B2

Reaction notes

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