Trifluoroacetic acid → 2-Methoxy-4-piperazin-1-yl-[1,3,5]triazine

HRID 1820760Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[C:18]([O:20][CH3:21])[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[CH3:21][O:20][C:18]1[N:19]=[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:15]=[CH:16][N:17]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 69038439HCID 69038439, compound

Product 1

HCID 690376682-Methoxy-4-piperazin-1-yl-[1,3,5]triazine

Procedure

Prepared in analogy to example 4.10(c) from 4-(4-Methoxy-[1,3,5]triazin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester and trifluoroacetic acid. MS (m/e): 196.4 (MH+, 100%)

Sources & evidence

ORD record: ord-140564442c42480d8e309d5866e37b3d
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07605163B2

Reaction notes

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