反应详情

温度

80 °C

A mixture of 4.9 mmol 4-chloro-2-fluorobenzotrifluoride, 5.9 mmol n-Boc-piperazine, 0.05 mmol palladium acetate, 6.9 mmol sodium-t-butoxide and 0.49 mmol 2-(di-t-butylphosphino)biphenyl in 10 ml toluene was heated for 16 h at 80° C. After cooling to RT, the mixture was diluted with ether; the suspension was filtered over decalite; and the filtrate evaporated. The residue was purified on silica eluting with a gradient of heptane/EtOAc to yield after evaporation the title compound.

1. temperatureAfter cooling to RT
2. filtrationthe suspension was filtered over decalite
3. customand the filtrate evaporated
4. customThe residue was purified on silica eluting with a gradient of heptane/EtOAc
5. customto yield
6. customafter evaporation the title compound