反应详情

温度

90 °C

To 7.6 mmol 1,2,3-trifluoro-4-(propane-2-sulfonyl)-benzene in 20 ml N,N-dimethylacetamide was added 15.9 mmol tert-butyl-1-piperazine carboxylate, and the mixture was heated at 90° C. for 1 h. The mixture was then cooled to room temperature and concentrated in vacuo. The residue was chromatographed on silica gel (eluant: ethyl acetate/heptane 1:2) to afford the title compound.

1. temperatureThe mixture was then cooled to room temperature
2. concentrationconcentrated in vacuo
3. customThe residue was chromatographed on silica gel (eluant: ethyl acetate/heptane 1:2)