Hydrochloric Acid → Rac-2-methyl-1-(4-trifluoromethyl-phenyl)-piperazine hydrochloride

HRID 1820814Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH:10]([CH3:24])[CH2:9]1)=O)(C)(C)C.[ClH:25]>O1CCOCC1.CCOCC>[ClH:25].[CH3:24][CH:10]1[CH2:9][NH:8][CH2:13][CH2:12][N:11]1[C:14]1[CH:15]=[CH:16][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:18][CH:19]=1

Participants

Conditions

Temperature: 90 °C

Procedure

To 0.58 mmol rac-3-methyl-4-(4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester in 3 ml dioxane was added 8.7 mmol HCl (as a 4 M solution in dioxane), and the mixture was heated at 90° C. for 3 h. The mixture was then cooled 0° C. and diluted with 10 ml ether. The ensuing white crystals were collected by filtration, washing with ether, and dried in vacuo to afford the title compound.

Workup

temperatureThe mixture was then cooled 0° C.
filtrationThe ensuing white crystals were collected by filtration
washwashing with ether
customdried in vacuo

Sources & evidence

ORD record: ord-a8adcd6144fc4095bf1cfebd24c187c4
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07605163B2

Reaction notes

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